忧伤

A profound melancholy seized him.

His brow was sad.

Mourning is all over his face.

gentle sadness

eat one's heart out

suffer excessive distress; be grief-stricken

die of grief/broken heart

cause sb's distress

sink into melancholy

chase away one's distress

assuage one's grief

intensify one's grief

feel sad and worried; suffer distress